Is the Buffalo Bills vs. San Francisco 49ers match a highlight of the 13th round of the NFL? Undoubtedly. The teams haven’t had the chance to measure their strengths against each other for several years, which is taken into account in our prediction, based on all useful information.

Buffalo

Buffalo is one step away from climbing to the top spot in the league table, which clearly gives a solid boost of motivation. The team has secured a win streak of six games, thereby challenging Kansas. Sean McDermott’s charges have fine-tuned their coordination to the utmost level, allowing them to easily adjust to all competitors, as well as confidently maintain the advantage earned. In attack, the guys operate with maximum efficiency, only second to Baltimore in statistical indicators.

San Francisco

In contrast, San Francisco has been showing mediocre football this season, which has come as a huge surprise to the public. The team remains the reigning runner-up of the tournament, but this time it risks not even making it to the playoffs. In Kyle Shanahan’s squad’s infirmary, there remains a number of key performers, which hinders displaying their best qualities. A week earlier, the Californians suffered a humiliating defeat to Green Bay (10:38), and before that, they lost to Seattle in an uncompromising fight (17:20).

Editorial Prediction

In this encounter, San Francisco, in our firm belief, will perform well in attack despite the obvious decline. Buffalo cannot boast an ironclad defense, and we believe that in individual quarters it will face significant difficulties. An individual total for the visiting club over 18.5 is a reasonable option for the match.